Estradiol: What It Means for Your Health
Estradiol (E2) is the most potent and abundant form of estrogen, primarily produced by the ovaries in women and in smaller amounts by the adrenal glands and fat tissue in both sexes. It regulates the menstrual cycle, supports pregnancy, maintains bone density, protects cardiovascular health, and influences mood and brain function. Estradiol levels fluctuate significantly during the menstrual cycle and decline sharply during menopause.
Reference Range
Reference ranges may vary between laboratories, age groups, and sexes. The values shown are general adult reference ranges. Always compare your results to the specific range provided by your testing laboratory.
What Is Estradiol?
Estradiol (E2) is the most potent and abundant form of estrogen, primarily produced by the ovaries in women and in smaller amounts by the adrenal glands and fat tissue in both sexes. It regulates the menstrual cycle, supports pregnancy, maintains bone density, protects cardiovascular health, and influences mood and brain function. Estradiol levels fluctuate significantly during the menstrual cycle and decline sharply during menopause.
Commonly included in:
What Does High Estradiol Mean?
Elevated estradiol in women may indicate ovarian cysts, estrogen-producing tumors, or obesity (fat tissue produces estrogen). In men, high estradiol can cause gynecomastia (breast enlargement), erectile dysfunction, and infertility. Estradiol levels naturally rise significantly during pregnancy. Elevated levels may also increase the risk of estrogen-receptor-positive breast cancer.
What Does Low Estradiol Mean?
Low estradiol in women causes hot flashes, night sweats, vaginal dryness, bone loss, mood changes, and irregular or absent periods. It is characteristic of menopause, premature ovarian failure, eating disorders, excessive exercise, and pituitary disorders. Low estradiol in men may contribute to osteoporosis and increased fracture risk.
Related Biomarkers in Hormones
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This information is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Reference ranges may vary between laboratories. Always consult a qualified healthcare professional for interpretation of your blood test results and before making any health decisions.