🔩 Iron Studies

Transferrin Saturation: What It Means for Your Health

Transferrin saturation is calculated by dividing serum iron by TIBC and multiplying by 100. It indicates what percentage of the body's iron-carrying capacity is being used. It provides a more complete picture of iron status than serum iron alone and is a key screening marker for hereditary hemochromatosis.

Full Name
Transferrin Saturation (TSAT)
Normal Range
20–50 %
Also Known As
Transferrin Sat, TSAT, Iron Saturation

Reference Range

LowNormal: 20–50 %High

Reference ranges may vary between laboratories, age groups, and sexes. The values shown are general adult reference ranges. Always compare your results to the specific range provided by your testing laboratory.

What Is Transferrin Saturation?

Transferrin saturation is calculated by dividing serum iron by TIBC and multiplying by 100. It indicates what percentage of the body's iron-carrying capacity is being used. It provides a more complete picture of iron status than serum iron alone and is a key screening marker for hereditary hemochromatosis.

Commonly included in:

Iron StudiesHemochromatosis Screening

What Does High Transferrin Saturation Mean?

Above 50 %

Transferrin saturation above 45-50% suggests iron overload and is a primary screening tool for hereditary hemochromatosis. It can also be elevated in hemolytic anemias, liver disease, and excessive iron supplementation. Saturation above 60% strongly suggests genetic iron overload.

What Does Low Transferrin Saturation Mean?

Below 20 %

Low transferrin saturation (below 20%) indicates iron deficiency, even if hemoglobin is still normal. It means the body's iron-carrying capacity is underutilized. Common in iron-deficient diets, chronic blood loss, and malabsorption conditions.

Related Biomarkers in Iron Studies

Ferritin
Iron storage protein that reflects your body's total iron reserves.
Range: 20–250 ng/mL
Iron
Amount of iron circulating in your blood.
Range: 60–170 ug/dL
TIBC
Maximum amount of iron your blood can carry.
Range: 250–400 ug/dL

Track Your Transferrin Saturation Over Time

Upload your blood test results to Hemoly and see how your Transferrin Saturation levels change over time. Get trend analysis, educational insights, and a personal health timeline.

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Medical Disclaimer

This information is for educational purposes only and is not intended as medical advice, diagnosis, or treatment. Reference ranges may vary between laboratories. Always consult a qualified healthcare professional for interpretation of your blood test results and before making any health decisions.